Precise 3D deep brain stimulation electrode location based on multimodal neuroimage fusion

Abstract

The success of neurosurgery strongly depends on the pre-neurosurgical evaluation phase, in which the delineation of the areas to be removed or to be stimulated must be very accurate. For patients undergoing Deep Brain Stimulation (DBS) it is vital the delineation of the target area prior to surgery, and after the implantation of the DBS lead to confirm the electrodes positioning. In this paper we present a system to accurately determine the 3D position of DBS electrodes implanted within the brain of Parkinson and Dystonia patients. The system was tested using a multimodal dataset from 16 patients (8 with Parkinson's disease and 8 with dystonia) and, on average, the differences between the detected electrodes positions and the ones estimated manually by an experienced physician were less than a voxel in all cases. Copyright