Please use this identifier to cite or link to this item: http://repositorio.inesctec.pt/handle/123456789/6420
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dc.contributor.authorRozanski,VEen
dc.contributor.authorWick,Fen
dc.contributor.authorNádia Moreira Silvaen
dc.contributor.authorAhmadi,SAen
dc.contributor.authorKammermeier,Sen
dc.contributor.authorJoão Paulo Cunhaen
dc.contributor.authorBoetzel,Ken
dc.contributor.authorVollmar,Cen
dc.date.accessioned2018-01-16T16:08:26Z-
dc.date.available2018-01-16T16:08:26Z-
dc.date.issued2016en
dc.identifier.urihttp://repositorio.inesctec.pt/handle/123456789/6420-
dc.identifier.urihttp://dx.doi.org/10.1016/j.baga.2016.02.002en
dc.description.abstractBackground: Hemiballism may arise as a rare consequence of focal basal ganglia lesions. Pathophysiologically, there is a controversy between the role of the STN as the exclusive lesion localization as opposed to several brain regions in which lesions may induce hemiballism. This is most likely due to a motor circuit affection. Objectives: To study the affection of neural networks in the pathogenesis of hemiballism. Methods: We analysed focal vascular lesions inducing hemiballism (n = 8), their localizations and connectivity profiles. Probabilistic tractography (FSL: http://fsl.fmrib.ox.ac.uk/fsl/) was used to study connectivity. Results: Lesions inducing hemiballism were distributed across several anatomic regions (basal ganglia, thalamus, caudate, internal capsule) without a clear predilection. However, we detected increased connectivity for these lesions toward the STN and mesial cortical motor regions (pre-SMA/SMA). These regions are interconnected via subthalamo-pallido-thalamo-cortical networks. Conclusions: We provide evidence for the involvement of the subthalamo-pallido-thalamic pathways in the pathogenesis of hemiballism, which is consistent with data on experimental hemiballism in animals. Electrophysiological basal ganglia recordings and functional MRI would complement our findings to assess the activation patters within these circuits.en
dc.languageengen
dc.relation5864en
dc.relation5875en
dc.rightsinfo:eu-repo/semantics/embargoedAccessen
dc.titleA connectivity-based approach to the pathophysiology of hemiballismen
dc.typearticleen
dc.typePublicationen
Appears in Collections:C-BER - Articles in International Journals

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