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Title: Computational modeling of red blood cells trapping using Optical Fiber Tweezers
Authors: Joana Isabel Paiva
Ana Rita Ribeiro
Pedro Jorge
Carla Carmelo Rosa
João Paulo Cunha
Issue Date: 2017
Abstract: Optical Tweezers (OT) are able to trap/manipulate dielectric particles with few microns in a contactless manner due to forces exerted on them by a strongly focused optical beam. OT are being applied in Biology/Medicine, especially Optical Fiber Tweezers (OFT), for being simpler and more flexible than the conventional setups. Despite of the trapping phenomena of symmetrical particles by OFTs being already modeled, effects regarding complex bodies remain poorly understood. Here we provide a 2D characterization of the trapping forces exerted by a laser OFT on a geometric form of a Red Blood Cell (RBC), occupying different positions in a grid, using the method proposed by Barnett&Loudon. Comparisons were made between the forces exerted on a RBC having the mean normal size; a RBC with 80% of the normal size and an 1.5µm circular particle, due to the size and shape variability of biological-derived structures. The influence of RBCs inclination angles regarding its major axis on trapping performance was also evaluated for angles of p/4 and p/2. Simulation results showed that trapping phenomena are possible for all the conditions evaluated, as well as calculated trapping forces range was according with the literature (pN). We observed that, despite of modeled particles having the same optical characteristics, features such as particle geometry, size, position and inclination degree influence trapping. Trapping forces magnitude was higher for RBC relatively to the circular symmetrical particle; for large RBCs than RBCs with smaller dimensions; and for inclined RBCs than erythrocytes horizontally aligned. Those results reinforce the importance of modeling optical experiments to determine relevant parameters which affect trapping performance. © 2017 IEEE.
metadata.dc.type: conferenceObject
Appears in Collections:C-BER - Articles in International Conferences
CAP - Articles in International Conferences

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