Please use this identifier to cite or link to this item: http://repositorio.inesctec.pt/handle/123456789/5138
Title: Probabilistic description of model set response in neuromuscular blockade
Authors: Conceição Nunes Rocha
Lemos,JM
Mendonca,TF
Silva,ME
Issue Date: 2014
Abstract: This work addresses the problem of computing the time evolution of the probability density function (pdf) of the state in a nonlinear neuromuscular blockade (NMB) model, assuming that the source of uncertainty is the knowledge about one parameter. The NMB state is enlarged with the parameter, that verifies an equation given by its derivative being zero and has an initial condition described by a known pdf. By treating the resulting enlarged state-space model as a stochastic differential equation, the pdf of the state verifies a special case of the Fokker-Planck equation in which the second derivative terms vanish. This partial differential equation is solved with a numerical method based on Trotter’s formula for semigroup decomposition. The method is illustrated with results for a reduced complexity NMB model. A comparison of the predicted state pdf with clinical data for real patients is provided. © Springer International Publishing Switzerland 2014.
URI: http://repositorio.inesctec.pt/handle/123456789/5138
http://dx.doi.org/10.1007/978-3-319-01857-7_39
metadata.dc.type: conferenceObject
Publication
Appears in Collections:LIAAD - Articles in International Conferences

Files in This Item:
File Description SizeFormat 
P-00G-6VH.pdf260.81 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.