Aptamer-based fiber sensor for thrombin detection

dc.contributor.author Luís Carlos Coelho en
dc.contributor.author José Almeida en
dc.contributor.author José Luís Santos en
dc.contributor.author Pedro Jorge en
dc.contributor.author Martins,MCL en
dc.contributor.author Diana Viegas en
dc.contributor.author Queiros,RB en
dc.date.accessioned 2017-12-20T21:35:31Z
dc.date.available 2017-12-20T21:35:31Z
dc.date.issued 2016 en
dc.description.abstract The detection of thrombin based on aptamer binding is studied using two different optical fiber-based configurations: long period gratings coated with a thin layer of titanium dioxide and surface plasmon resonance devices in optical fibers coated with a multilayer of gold and titanium dioxide. These structures are functionalized and the performance to detect thrombin in the range 10 to 100 nM is compared in transmission mode. The sensitivity to the surrounding refractive index (RI) of the plasmonic device is higher than 3100 nmRIU(-1) in the RI range 1.335 to 1.355, a factor of 20 greater than the sensitivity of the coated grating. The detection of 10 nM of thrombin was accomplished with a wavelength shift of 3.5 nm and a resolution of 0.54 nM. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) en
dc.identifier.uri http://repositorio.inesctec.pt/handle/123456789/4567
dc.identifier.uri http://dx.doi.org/10.1117/1.jbo.21.8.087005 en
dc.language eng en
dc.relation 5799 en
dc.relation 347 en
dc.relation 4636 en
dc.relation 5256 en
dc.relation 3565 en
dc.rights info:eu-repo/semantics/embargoedAccess en
dc.title Aptamer-based fiber sensor for thrombin detection en
dc.type article en
dc.type Publication en
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