Please use this identifier to cite or link to this item: http://repositorio.inesctec.pt/handle/123456789/4567
Title: Aptamer-based fiber sensor for thrombin detection
Authors: Luís Carlos Coelho
José Almeida
José Luís Santos
Pedro Jorge
Martins,MCL
Diana Viegas
Queiros,RB
Issue Date: 2016
Abstract: The detection of thrombin based on aptamer binding is studied using two different optical fiber-based configurations: long period gratings coated with a thin layer of titanium dioxide and surface plasmon resonance devices in optical fibers coated with a multilayer of gold and titanium dioxide. These structures are functionalized and the performance to detect thrombin in the range 10 to 100 nM is compared in transmission mode. The sensitivity to the surrounding refractive index (RI) of the plasmonic device is higher than 3100 nmRIU(-1) in the RI range 1.335 to 1.355, a factor of 20 greater than the sensitivity of the coated grating. The detection of 10 nM of thrombin was accomplished with a wavelength shift of 3.5 nm and a resolution of 0.54 nM. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
URI: http://repositorio.inesctec.pt/handle/123456789/4567
http://dx.doi.org/10.1117/1.jbo.21.8.087005
metadata.dc.type: article
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Appears in Collections:CAP - Articles in International Journals
CRAS - Articles in International Journals

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